[Article in Japanese]
Hori S.
Department of Ophthalmology, Tokyo Women's Medical University, Japan.
This paper conducts an analysis and discussion of the pathogenesis and treatment strategies for diabetic retinopathy, a major cause of blindness. Histological examination of experimental and biopsied material found that the pericyte necrosis and basement membrane thickening were responsible for sclerosis of retinal microvessels. The macrophages were noted in the pathogenesis of retinopathy. The cytokines of intraocular fluid were analyzed, and the vascular endothelial growth factor and intercellular adhesion molecule-1 were found to be closely related to retinopathy and macular edema. These findings suggest that the inflammation lead to the complex pathology of retinopathy. Anti-inflammatory drugs need to be included in the therapeutic strategy. The Diabetic Eye Notebook is an important source of information for patients who were lost to followup.
PMID: 20387536
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