Byung-Wan L, Jun H, Yim HJ, Park JB, Woo H, Yoo HJ.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Department of Internal Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 150-030, Republic of Korea.
The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic beta-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia. Copyright © 2010. Published by Elsevier Inc.
PMID: 20045532
| < Prev | Next > |
|---|
