[Article in Dutch]
de Valk HW.
Universitair Medisch Centrum Utrecht, afd. Interne Geneeskunde, Utrecht, The Netherlands. This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Treatment of gestational diabetes mellitus is a hotly debated topic. In a recent randomized trial, metformin as a monotherapy achieved maternal and neonatal outcomes comparable to insulin treatment. In 2000, a randomized trial reported a similar favourable result with glibenclamide. The logical conclusion would be that either drug could already have a place in the usual treatment strategy in gestational diabetes. However, a number of major methodological, design and interpretation issues and shortcomings have led to the conclusion that such a point of view is not currently tenable. Therefore, neither metformin nor glibenclamide can yet have an established place as monotherapies in gestational diabetes; they can be used only in exceptionally cases.
PMID: 19785815
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