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Home Medication Biguanides Metformin Metformin-associated hepatotoxicity

Metformin-associated hepatotoxicity

Med Intensiva. 2009 Dec 31.

[Article in Spanish]

Olivera-González S, de Escalante-Yangüela B, Velilla-Soriano C, Amores-Arriaga B, Martín-Fortea P, Navarro-Aguilar ME.

Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes. It produces non-specific gastrointestinal symptoms in 10-30% of the patients. Lactic acidosis is the most serious side effect, so it must not be administered to patients with renal, liver, or heart insufficiency. Only a few cases of hepatotoxicity due to this drug have been documented. We report the case of a patient with type 2 diabetes mellitus and recent use of metformin who developed serious liver injury, followed by a favorable evolution. Copyright © 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.

PMID: 20045581

 

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