[Article in Spanish]
Olivera-González S, de Escalante-Yangüela B, Velilla-Soriano C, Amores-Arriaga B, Martín-Fortea P, Navarro-Aguilar ME.
Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes. It produces non-specific gastrointestinal symptoms in 10-30% of the patients. Lactic acidosis is the most serious side effect, so it must not be administered to patients with renal, liver, or heart insufficiency. Only a few cases of hepatotoxicity due to this drug have been documented. We report the case of a patient with type 2 diabetes mellitus and recent use of metformin who developed serious liver injury, followed by a favorable evolution. Copyright © 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.
PMID: 20045581
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