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Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update

More than ca. 1200 plant species have been recorded to be used empirically worldwide for their alleged hypoglycaemic activity.
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Immunotherapy of type 1 diabetes: where are we and where should we be going?

Depending on the time of therapeutic intervention in the T1D disease process, antigen-specific immunoregulatory strategies may be employed as monotherapies, or in combination with short-term tolerance-promoting immunoregulatory drugs and/or drugs promoting differentiation of insulin-producing beta cells from endogenous progenitors.
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Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Together with our previous report, we strongly suggest BBR as an ideal medicine for T2DM with a mechanism different from metformin and rosiglitazone.
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Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats

The efficacy of the bark extract was comparable with Tolbutamide, a well-known hypoglycemic drug.
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Hypoglycemic polysaccharides from the tuberous root of Liriope spicata

These results suggest that LSP1 and LSP2 show high potential to be explored as natural oral hypoglycemic agents.
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Effect of rimonabant on glycemic control in insulin-treated type 2 diabetes: the ARPEGGIO trial

Rimonabant improved glycemic control and cardiometabolic risk factors in patients with type 2 diabetes receiving insulin.
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Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice

These results suggest that osthole can alleviate hyperglycemia and could be potentially developed into a novel drug for treatment of diabetes mellitus.
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Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus

These results suggest that ADN gene therapy could be a clinically effective tool for the treatment of type 2 DM.
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alpha-Glucosidase inhibitory antihyperglycemic activity of substituted chromenone derivatives

Compound 4x may serve as an interesting new compound for the development of therapeutics targeted against diet-induced hyperglycemia in diabetes.
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The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK)

Future development of this herb (Paeoniae Radix) as a dietary supplement or drug should bring substantial benefits for the diabetic population.
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