Now, researchers at Stanford University present what they call an environment-wide association study (EWAS) or a systematic examination of the contributions of hundreds of factors in the development of Type 2 diabetes. This "enviromics" approach, which mirrors genome-wide association studies, harnesses high-speed computers and publicly accessible databases.
The first-of-its-kind study, which was funded by the National Institutes of Health (NIH), appears in the May 20, 2010, issue of PLoS One.
The authors examined 226 separate environmental factors like nutrition and exposure to bacteria, viruses, allergens and toxins. They found that certain factors, notably a pesticide derivative and the environmental contaminant PCB, were strongly associated with the development of diabetes. Other factors, including the nutrient beta-carotene, served a protective role.
The scientists describe their work as a demonstration that computational approaches can reveal as much about environmental contributions to disease as about genetic factors. They posit that the technique could be applied to other complex diseases like obesity, hypertension and cardiovascular disorders.
The authors acknowledge that many challenges remain, including the fact that, unlike the genome, "the environment is boundless."
Related article:
Patel CJ, Bhattacharya J, Butte AJ (2010) An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus. PLoS ONE 5(5): e10746.doi:10.1371/journal.pone.0010746.
In addition to NIGMS, the work was supported by NIH’s National Library of Medicine and National Institute on Aging.
NIGMS is a part of NIH that supports basic research to increase our understanding of life processes and lay the foundation for advances in disease diagnosis, treatment, and prevention. For more information on the Institute's research and training programs, see http://www.nigms.nih.gov.
The National Institutes of Health (NIH) - The Nation's Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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