Diabetes PubMed

Lifestyle changes that include a nutritionally balanced diet and increased physical activity (PA) are effective intervention options for persons with prediabetes who want to prevent progression to type 2 diabetes mellitus.

When lifestyle modification fails and in high-risk patients, medications such as metformin and/or acarbose are recommended. For high-risk patients and those who progress despite intensive lifestyle modification, thiazolidinediones are also recommended.

The results of non-pharmacological investigations documented that not only the incidence of newly diagnosed type 2 diabetes but cardiovascular risk factors and microangiopathic late complications could also be decreased by life-style modification in subjects with prediabetes (impaired glucose tolerance).

Although prevention of prediabetes is a huge challenge, a tight glycemic control with lifestyle modifications and antihyperglycemics like thiazolidinediones play a vital role in increasing the insulin sensitivity of tissues and decreasing the cardiovascular risk factor of diabetes.